Not sure how new or old this is but I figured I'd share it here anyway...
A recent (video) post on Synthtopia
really managed to catch my attention; a blind dude who's using Reason to create a good tune. Personally I think it sounds pretty cool too.
See this article
To me this proves once again how straight forward Reason usage can be if you manage to look beyond the rack, which could look a bit daunting at first (no pun intended).