Just pull down the master fader until you have no clips in the master anymore. Any clipping in the signal path should not matter too much as reason internally uses at least 32bits (in REs) or 64bit (in its native signal flow) and has enough headroom. Some plugins might not react too nicely towards too high levels though, but I didn't experience any serious issues in this regard (as opposed to Logic for example).
Plugin latency issues? Phasing on parallel channels? Want to know the real latency of your audio interface? Try the VMG-01!
Professional Audio Engineer at Theater Bremen, Germany • Part Time Programmer