I play Reason instruments with my EWI via MIDI -> USB (a 1x1 Emu interface) so yes, absolutely. It's like using any other MIDI controller at that point. As long as your drums are transmitting the proper notes for the sounds you're wanting to play to trigger them.
Say you want to use synthesized drums and have a Kong kit loaded. Your kick pedal should transmit note C1 to trigger pad 1 (typically a kick sound in most presets), C#1 is pad 2, etc. I don't know about 'choke' groups, though, say, for realistic hi hat playing. Can MIDI drum sets transpose the transmitted note up one when you use the hat pedal? o.O
You can play any instrument in Reason this way if you wanted, though I imagine most drummers would gravitate to Kong or NN-XT as previously stated