I think having 2 monitors really solves any issues. I know the software shouldn't demand such a thing, but nevetheless, since I used to work with Reason versions 2 & 3 and was used to a single column rack layout, I still stick with that setup. The right-to-left rack is indeed an utter mess to me.
The right monitor can be used for the sequencer and SSL mixer and the left simply the rack. I use a smaller monitor for the rack on a lower resolution setting so that the rack items are larger and easier to see.