I have an APC40 myself. i tried it in other software (Traktor) with different templates, but have to addmit, its just made for Live, nothing else.
me & my friend have done livesets using Ableton + Reason ReWired, with the APC controlling Live & a second midi-keyboard controlling Reason.
i personally dont think the APC has the layout or functions i would want to use in Reason.
Besides that, if you see what Push now does with Live 9, i become to wonder if the Props could work together wit a hardware manufacturer to built a Midi-controller kindad designed for reason only...
Don't have much ideas myself, but a step-sequencer useable for ReDrum or Thor would be a must have on that