Several for me:
Scenario #1: Fender Amp with stereo ASIO driver (input only but no recording latency at all). I still need my primary output for monitors.
Scenario #2: Using my ADAT IO as sends and/or return from/into Reason and another DAW for effects, soft synths, misc stuff. This could be even more handy in R7.
Richmond, VA, USA
Reason 7 - Studio One Pro V2.5
Optiplex780 8G Win7 & Dell Latitude E6410 4G Win7 64 bit
Presonus AudioBox1818 - Focusrite VRM - Fender SuperChamp X2
MAudio Oxygen61 - Akai MPD26 - iPad2