Here's a piece I just did to see how far I could get inside Reason for a Fender tube amp, clean and distorted, with a Les Paul. It came out OK, but I'm still waiting for Kuassa Vermillion and Creme to come out as RE's. I used the tube overdrive in Scream, the Faturator and a Pulverizer to get the distorted lead sound, and numerous Softube Trident A-Range EQ's in series to get the clean sound (all at +3 dB at 3K and 50% saturation). No Line6 amps because that made them sound tinny, just Line6 cabinets for speaker emulation.
John - San Francisco www.soundcloud.com/john-richards
Reason 7; 27" iMac; Akai MPK88; Konnekt6; Amplitube; Miroslav Gold; Fender Strat, Tele, Jazz Bass, Blues Jr III, SCXD; Spector Bass; Agile Les Paul; Ergo Bass; Zero-G Total Rex; Trident A-Range; RE-2A; Vermilion; Creme; Revival; Futurator; Glitch; Logic Studio 9; Reaktor 5.8.