So I am currently running:
Windows 7 SP1 64bit
Intel Core i5-2500K Sandy Bridge Quad-core
MSI P67A-GD65 SATA 6Gb/s USB 3.0 Motherboard
G.SKILL Ripjaws X Series 8GB DDR3 1333 Cas 7 Ram
HITACHI Deskstar 1.5TB 7,200 RPM SATA 6.0Gb/s 3.5" Hard Drive
Creative PCI Express X-Fi Titanium Fatal1ty Champion Series Sound Card
Edirol PCR-800 USB-powered midi controller.
I also have an Alesis io|2 interface and tried using that too...
So why in the world am I getting serious input latency? Reason 4 and Record 1 worked flawless with this rig, then when I just upgraded to Reason 6 it all went to hell in a hand basket