I've had similar issue with Reason detecting M-Audio controllers. Here are a couple things you can try.
1. Try a different USB 2.0 port (Not USB 3). For some reason my controller worked on one usb port but not the other. Unless... keep reading.
2. Delete multiple installed device drivers from the device manager.
Each time you plug in a usb device to each port, Windows creates a driver for that port in the device manager. So one device could have up to 4 drivers installed (1 for each usb port if you have 4). I fixed my issue by deleting all the drivers and letting windows re-detect it on the one I would using all the time. After that I had no issues with Reason ever detecting the M-Audio Controller
To delete all your drivers and start over:
Unplug your Axiom
Delete any controller that you installed in Reason and close it.
Go to Control Panel, Click System and then Device Manager.
Click on View, Show Hidden Devices.
Click the drop down arrow for Sound, Video and Game Controllers and find all the M-Audio stuff.
Uninstall all the devices that you see for the M-Audio Axiom
Close out the device manager and re-plug in your Axiom to the USB port that you plan to use (Remember only use this port in the future). It should install the driver for it.
Open Reason and try to auto detect the Axiom again.
This has always worked for me in the past. I've only noticed this with M-Audio controllers, (I've had the Oxygen 8, Oxygen 25, Axiom, Axiom Pro). I've never had this issue with the ports using my Line 6 FBV Express MkII.
Hope this helps!
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